Environmental Enrichment Upregulates Striatal Synaptic Vesicle-Associated Proteins and Improves Motor Function
نویسندگان
چکیده
منابع مشابه
Synaptic vesicle proteins
What are they called? The uptake and storage of neurotransmitters is taken care of by the imaginatively named ‘neurotransmitter transporter proteins’ (as well as by ion channels and a proton ATPase). The synaptic vesicle proteins in the membrane trafficking class have mostly been given the prefix ‘synapto’, from the Latin meaning ‘to attach together’, and a suffix supposed to reflect a particul...
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The recent identification of novel proteins associated with the membranes of synaptic vesicles has ignited the field of molecular neurobiology to probe the function of these molecules. Evidence is mounting that the vesicle proteins vamp (synaptobrevin), rab3A, synaptophysin, synaptotagmin (p65) and SV2 play an important role in regulated exocytosis, by regulating neurotransmitter uptake, vesicl...
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The functional integrity of neurons requires the bidirectional active transport of synaptic vesicles (SVs) in axons. The kinesin motor KIF1A transports SVs from somas to stable SV clusters at synapses, while dynein moves them in the opposite direction. However, it is unclear how SV transport is regulated and how SVs at clusters interact with motor proteins. We addressed these questions by isola...
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ژورنال
عنوان ژورنال: Frontiers in Neurology
سال: 2018
ISSN: 1664-2295
DOI: 10.3389/fneur.2018.00465